Keywords

• 3-alpha,6-alpha-Dihydroxy-5-beta-cholan-24-oic acid
• 3alpha,6alpha-Dihydroxy-5beta-cholan-24-saeure
• 3alpha,6alpha-Dihydroxycholanic acid

Quick Details

• ProName: Hyodeoxycholic acid
• CasNo: 83-49-8
• Molecular Formula: C24H40O4
• ProductionCapacity: /
• Purity: 99
• LimitNum: 0

Superiority

Details

This product is a bile acid extracted from pig bile and is a secondary bile acid. Can inhibit the formation of bile acid and dissolve fat, reduce cholesterol and triglycerides in the blood, suitable for I. Or type Ib hyperlipidemia, atherosclerosis. And it can stimulate bile secretion, making bile thinner without increasing solid content; It can also accelerate the excretion of gallbladder contrast agent from the liver and help with imaging. It can also promote the breakdown of intestinal fat and the absorption of fat soluble vitamins.

Preparation method
Add saturated lime water supernatant to fresh pig bile, heat to boiling to generate calcium bilirubinate, filter, and acidify the mother liquor with hydrochloric acid while hot until Congo red turns blue, precipitate a black gel like precipitate bound with bile acid, remove the emulsion, collect the precipitate, and obtain crude pig bile acid.
Take crude bile acid and add 1.5 times sodium hydroxide and 9 times water, heat and hydrolyze for more than 16 hours. After cooling, siphon off the upper pale yellow liquid, and add an appropriate amount of water to dissolve the precipitate. Add hydrochloric acid or sulfuric acid to the aqueous solution until the pH is between 3.0 and 3.5. Separate the sediment and wash with water until
Near neutral, vacuum dried to obtain crude pig deoxycholic acid. Take crude deoxycholic acid from pig and add 5 times the amount of ethyl acetate, then add 15% to 20% activated carbon, heat and reflux to dissolve and decolorize. After cooling, filter the residue, add 3 times the amount of ethyl acetate reflux, and filter. Combine the filtrate and then
Add 20% anhydrous sodium sulfate for dehydration. After filtering out sodium sulfate, the filtrate is concentrated to 1/5 to 1/3 of its original volume and allowed to cool for crystallization. Filter and separate the crystals, wash them with a small amount of ethyl acetate, and dry them under vacuum to obtain deoxycholic acid from pigs.

purpose
It is applicable to type Ia and Ib hyperlipidemia and atherosclerosis. It has a certain antibacterial effect on pertussis bacilli, diphtheria bacilli, Staphylococcus aureus, etc. Can be used as an anti-inflammatory drug to treat chronic bronchitis and viral upper respiratory tract inflammation in children. Suitable for cholangitis, cholecystitis, cholelithiasis, and other non obstructive cholestasis; Can accelerate the excretion of gallbladder contrast agent from the liver to aid in imaging. It can also promote the breakdown of intestinal fat and the absorption of fat soluble vitamins, and can be used for digestive disorders caused by liver and gallbladder diseases.
Usage and dosage: Oral administration, 0.15-0.3g/time, 2-3 times a day. Preparation tablets, each tablet is 0 15g.